Body Language Vitamin Company

Scientific Update December 2002

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Thank you very much for your interest in Body Language Vitamin Company’s Scientific Formulas

This is a scientific update as I had promised. It is also to thank you for visiting our website and or benefiting from our state of the art supplements. This update will keep you informed with important new research information.

I welcome you to visit our site Body Language Vitamin Co and use our Body Mass Index Calculator, take our copyrighted health scan and search our educational resources to learn all about your health concerns. These health tools are free to you and provide important information regarding your wellness.

This update will also introduce our all-natural highly effective Anti-cholesterol Formula. It is well known that high cholesterol is a major risk factor contributing to cardiovascular disease - the leading cause of death in the United States. In most cases, cholesterol levels can be lowered and managed medicinally and nutritionally. In fact, there are many completely-natural herbs and medicines that help to lower cholesterol levels.

Body Language Vitamins presents this unique and powerful anti-cholesterol supplement formulated from the finest natural ingredients, which have been gathered from around the world because of their proven effect in lowering cholesterol levels and reducing inflammation within the vessel (now believed to be a very important cause of heart disease). Using this combination of all natural herbs and supplements will significantly reduce your cholesterol and vessel wall inflammation. This supplement may also help to reduce the risk of coronary artery disease, stroke and other vascular disorders because reducing your cholesterol level by as little as 1% can reduce your risk for heart attack by 3%.

The Anti-cholesterol formula has compounds that are known to flush fats from your system, thus they will also wash away fat soluble vitamins that have not yet been absorbed (usually takes 30 minutes to 3 hours depending upon many variables. Another benefit because of this may be some weight loss.

Fish and Omega-3 Fatty Acid Intake and Risk of Heart Disease in Women (Published in JAMA April 10, 2002 Vol 287 No 14 Pg 1815-1821)

It is well documented that groups of people with a high consumption of fish (Asian's in fishing villages, Alaskan Natives etc) have a significantly lower risk for heart disease. It has been verified that the Omega-3 fatty acids are the active agent primarily responsible for the protective effect of fish. The mechanisms for this protection are diverse and very complex, but are felt to include a lowering of triglycerides (Harris WS J Lipid Res 1989;30:785-807), a reduction in the production of thromboxane A2 (this compound is intimately involved in coagulation-a lowering of this product leads to "thinner blood" (less apt to clot), however life always teeters on a critical balance, if thromboxane A2 is too low this can cause bleeding problems (Nair SSD et al J Nutr 1997;127:383-393), may reduce platelet stickiness (similar effect as aspirin) (Von Schacky C, Am J Clin Nutr 2000;71 (suppl):224S-227S), and evidence shows that fish oil improves the inside of the vessel wall-reduces inflammation and athersoclerosis (DeCanterina R et al Am J Clin Nutr 2000;71 (suppl) 213S-223S; Goodfellow J et al, J Am Coll Cardiol 2000;35:265-270). Many other mechanisms are probably involved -In short eat your fish! By the way Dark-meat fish (i.e. salmon, bluefish, swordfish, sardines, mackerel and tuna are some of the best fish to eat)

This particular study specifically examined dietary consumption from 84,688 female nurses enrolled in the Nurses' Health Study and followed these volunteers for 16 years. In conclusion, they found that women with a higher consumption of fish and omega-3 fatty acids have a statistically lower risk of coronary heart disease and death. Remember the number one cause of death in the USAis heart disease. Moral of this story: Watch your weight, eat a healthy diet, have fish 2-5 times per week (one time is better than zero times/week and two is better than one) and Body Language Vitamin will soon have its Essential oils formula (within 6-12 months) which will have significant amounts of omega-3's, the specific fish oils EPA (eicosopentaenoic acid) and DHA (docosohexanoic acid) and several oils critical for your health and well being; we think its well worth using on a daily basis

Body Language Vitamin Co.

Product File

Anti-Cholesterol Formula

The world’s most effective natural cholesterol-lowering agents all

combined into one powerful formula.

Ingredients: (three tablets contain) % Daily value

Artichoke (Cynara scolymnus) 100 mg *

(15% caffeoylquinic/chlorogenic acids)

Chitosan 300 mg *

Garlic 300 mg *

Chinese red yeast rice 500 mg *

Garcinia fruit 100 mg *

Myristica fragrans 100 mg *

Grapefruit pectin 400 mg *

Gugulipid 200 mg *

Beta-sitosterol 200 mg *

Hyaluronic acid 200 mg *

EDTA 200 mg *

Milk thistle 250 mg *

Policosanol 10 mg *

Vitamin B 12 12 mcg 200%

Folate 400 mcg 100%

Directions: Adults take three pills before bedtime. (Note: Be sure to take at least 2-3 hours after any fat-soluble vitamins since this supplement may flush fat-soluble nutritional supplements.)

Warning: Avoid using during during pregnancy or breast-feeding. Consult with a physician before using if you have allergies to shellfish, ragweed, chrysanthemums, marigolds, daisies nd many other herbs. May occasionally cause mild gastrointestinal symptoms, such as gas, heartburn, nausea or diarrhea.

It’s well known that high cholesterol is a major risk factor contributing to cardiovascular disease – the leading cause of death in the United States. In most cases, cholesterol levels can be lowered and managed medicinally and nutritionally. In fact, there are many completely-natural herbs and medicines that help to lower cholesterol levels.

Body Language Vitamins presents this unique and powerful anti-cholesterol supplement formulated from the finest natural ingredients, which have been gathered from around the world because of their proven effect in lowering cholesterol levels. Using this combination of all natural herbs and medicines will significantly reduce your cholesterol. This supplement may also help to reduce the risk of coronary artery disease, stroke and other vascular disorders because reducing your cholesterol level by as little as 1% can reduce your risk for heart attack by 3%.

The majority of your body’s cholesterol is produced in your liver while you sleep. Thus it is advisable to take three all-natural Body Language Vitamin Co Anti-cholesterol Formula capsules at bed time.

If you are taking other Body Language Vitamin Co supplements (in particular the Anti-Age/Energy, Antioxidant and Multivitamin Formulae) you should take ~ ½ of the supplements at breakfast and the other half with lunch or dinner. Then 2-4 hours later (prior to bedtime) you should take this outstanding cholesterol reducer.

The Anti-cholesterol formula has compounds that are known to flush fats from your system, thus they will also wash away fat soluble vitamins that have not yet been absorbed (usually takes 30 minutes to 3 hours depending upon many variables.

This supplement is very well tolerated. In a small number of users, it may cause loose stools, and increased flatulence. In very few people, it may cause liver function tests to be elevated. Therefore, it is advisable to have your liver function tested before taking this supplement, and then once again 3 months and 6 months later. If there is no significant change, then for good health promotion/prevention, you should check your liver function every 6-12 months. If there is any significant elevation in your liver enzymes, then you should discontinue this product immediately. The risks mentioned are much less likely than with prescription anti-cholesterol pills.

You should discontinue this product 14 days prior to any surgical procedure as there is a slight risk of increased bleeding (primarily from the garlic).

This supplement is made without yeast, sugars, preservatives, artificial coloring or flavoring, wheat, corn or milk. To enhance bioavailability and absorption, this supplement is prepared in a base of eicosopentanoic acid, phosphatidylcholine, and acidophilus with growth factors. This supplement meets or exceeds all USP specifications and dissolvability tests, and is made in a sterile laboratory that meets all FDA requirements

Claims:

Many of these herbs and natural ingredients have been proven to have direct cholesterol lowering effects -- from 5-30% or more…

In studies, liquid extracts of the roots and leaves of artichokes have played a role in increasing bile output, which helps the liver to regulate its production of cholesterol. Therefore, studies suggest artichokes may also play a role in lowering cholesterol, and thus helping to prevent heart disease.¹

Chitosan -- a dietary fiber derived from a combination of sugar and protein from shellfish -- has been shown to be beneficial for promoting mild reduction in fat absorption and serum levels of LDL (bad) cholesterol. It some cases, it has helped to lower cholesterol by more than 30%. ^{2, 3}

Garlic has long been recognized for its benefits in promoting cardiovascular health, specifically for reducing serum cholesterol levels, as well as preventing blood clotting and lowering blood pressure. ^{4, 5, 6} Studies have shown that garlic extract has beneficial effects on the lipid profile and blood pressure of moderately hypercholesterolemic people, and that in some cases, when used for 4-25 weeks, garlic usually lowers total cholesterol levels by about 4-12%. ^{7, 8, 9}

Red yeast rice has been shown to have a number of heart-healthy benefits, including lowering levels of LDL (bad) cholesterol, increasing levels of HDL (good) cholesterol, and lowering levels of triglycerides (Bad fat cells). ^{10, 11, 12}

Garcinia contains hydroxycitric acid (HCA), which is known for inhibiting fat production and suppressing appetite, as well as reducing blood lipids and increasing fat oxidation/mobilization. ¹³ In animal studies, HCA appears to be effective in both lean and obese rats, where it can reduce food intake, body weight, body fat accumulation, fat cell size and serum triglycerides.¹⁴

Grapefruit pectin has been shown as an effective cholesterol-lowering agent. ^{15, 16, 17}

Studies have shown gugulipid is just as effective for lowering cholesterol and triglyceride levels as certain prescription medications, and that it inhibits the formation of artery-hardening plaque. In addition, it has been found that active ingredients called guggulsterones encourage levels of cholesterol and fat to drop. ¹⁸

Beta-sitosterol is a plant-derived sterol compound structurally similar to cholesterol. However, sitosterol and its related compound, sitosterolin, are poorly absorbed from the gastrointestinal tract, which makes them effective for controlling cholesterol levels - due largely to an interference with normal cholesterol absorption from the diet. ^{19, 20, 21, 22, 23} In some cases, sterol compounds have decreased cholesterol absorption by as much as 50%. ²⁴

There is vast scientific evidence to support the effect of milk thistle in protecting and regenerating liver tissue, and therefore, decreasing liver and bile cholesterol. ^{25, 26}

Policosanol helps lower cholesterol levels by slowing the body's own production of cholesterol in the liver, as well as reducing the risk of blood clots and enhancing circulation. Medical studies have shown that policosanol can reduce both total cholesterol and LDL (bad) cholesterol by about 10-20%. ^{27, 28, 29}

Vitamin B12 works closely with folic acid to positively affect DNA synthesis, blood cell formation, nervous system maintenance and heart health. ^{30, 31, 32, 33}

References:

1. Gebhardt R. Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes of artichoke (cynara scolymus L.) extracts. J Pharm & Exp Ther, 1998, Vol 286 (3): 1122-286.

2. Ormrod DJ, Holmes CC, Miller TE. Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis. Atherosclerosis, 1998 June, 138 (2): 329-34.

3. Wuolijoki E, Hirvela T, Ylitalo P. Decrease in serum LDL cholesterol with microcrystalline chitosan. Methods Find Exp Clin Pharmacol. 199 June 21 (5): 357-61.

4. Arora RC, Arora S, Nigam P. Rationale of garlic use in ischemic heart disease? Mater Med Pol. 1985 Jan-Mar, 17 (1): 48-50.

5. Fogarty M. Garlic's potential role in reducing heart disease. Br J Clin Pract. 1993 Mar-Apr, 47 (2): 64-5.

6. Randerson K. Cardiology update: Garlic and the healthy heart. Nurs Stand. 1993 Apr 14-20, 7 (30): 51.

7. Silagy C, Neil A. Garlic as a lipid lowering agent – a meta-analysis. JR Coll Physicians Lond 1994, 28: 39-45.

8. Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol: A meta-analysis. Ann Intern Med 1993, 119: 599-605.

9. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypersholesterolemia: A meta-analysis of randomized clinical trials. Ann Intern Med 2000, 133: 420-9.

10. Heber D, et al. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 1999, 69: 231-6.

11. Wang J, Lu An, Chi J. Multicenter clinical trial of the serum lipid-lowering effects of a monoascus purpureus (red yeast) rice preparation from traditional Chinese medicine. Cur Ther Res 1997, 58: 964-78.

12. MedServ Medical News. Dietary supplement lowers cholesterol. www.medserv.dk/health/1999/03/26/story01.htm (Accessed 2 August 2000. Am Heart Assn. Am Heart Assn meeting report: Chinese condiment cuts blood cholesterol.)

13. Badmaev V, Majeed M, Conte AA. Garcinia cambogia for weight loss. JAMA. 1999 Jul 21, 282 (3): 233-4;

14. Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11, 280 (18): 1596-600.

15. Veldman FJ, nair CH, Vorster HH, et al. Dietary pectin influences fibrin network structure in hypercholesterolaemic subjects. Throm Res 1997, 86 (3):183-96.

16. Cerda JJ, Robbins FL, Burgin CW, et al. The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle. Clin Cardiol 1988,11 (9): 589-94.

17. Hillman LC, Peters SG, Fisher CA, et al. The effects of the fiber components pectin, cellulose and ignin or serum cholesterol levels. Am J Clin Nutri 1985, 42 (2): 207-13.

18. Nityanand S, Srivastava JS, Asthana OP. Clinical trials with gugulipd: A new hypolipidaemic agent. J Assoc Phys India1989, 37(5): 323-8.

19. Becker M, Staab D, Von Bergmann K. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J Pediatr 1993 Feb, 122 (2): 292-6.

20. Briones ER, Steiger D, Palumbo PJ, Kottke BA. Primary hypercholesterolemia: effect of treatment on serum lipids, lipoprotein fractions, cholesterol absorption, sterol balance, and platelet aggregation. Mayo Clin Proc1984 Apr, 59 (4): 251-7.

21. Drexel H, Breier C, Lisch HJ, Sailer S. Lowering plasma cholesterol with beta-sitosterol and diet. Lancet, 1981 May 23, 1 (8230): 1157.

22. Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 1999 Jun, 69 (6): 1144-50.

23. Parsons HG, Jamal R, Baylis B, Dias VC, Roncari D. A marked and sustained reduction in LDL sterols by diet and cholestyramine in beta-sitosterolemia. Clin Invest Med 1995 Oct, 18 (5): 389-400.

24. Law M. Plant Sterol and stanol margarines and health. BMJ 2000, 320: 861-864.

25. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998 Feb, 93 (2): 139-43.

26. Luper S. A review of plants used in the treatment of liver disease: part 1. Altern Med Rev 1998 Dec, 3 (6): 410.

27. Canetti M, Moreira M, Mas R, Illnait J, Fernandez L, Fernandez J, Diaz E, Castano G.

A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. Int J Clin Pharmacol Res 1995, 15 (4):159-65.

28. Menendez R, Fernandez SI, Del Rio A, Gonzalez RM, Fraga V, Amor AM, Mas RM. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res 1994, 27 (3-4): 199-203.

29. Torres O, Agramonte AJ, Illnait J, Mas Ferreiro R, Fernandez L, Fernandez JC. Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care 1995 Mar, 18 (3): 393-7.

30. Woo KS, Chook P, lolin YI, et al. Folic Acid improves arterial endothelial function in adults with hyperhomocysteinemia. J Am Coll Cardiol 1999, 34: 202-6.

31. Chao CL, Chien KL, Lee YT. Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by postmethionine load hyperhomocysteinemia. Am J Cardiol 1999, 84:1359-61.

32. Usui M, Matsuoka H, Miyazaki H, et al. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid. Clin Sci (Colch) 1999, 96: 235-9.

33. Voutilainen S, Lakka TA, Porkkala-Sarataho E, et al. Low serum foltae concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.

Please note: Body Language Vitamin Co/Michael D. Seidman, MD, FACS reserve all rights to this proprietary information. Any use of this information without the express written consent of BLV Co or Michael D. Seidman, MD is considered a violation of copyright/trademark laws and persons knowingly or unknowingly found guilty of copying or using this information will be punished to the fullest extent of the law.

Body Language Vitamin Company’s mission is to promote your health and wellness through responsible lifestyle choices and appropriate supplementation.

I hope you have found this information valuable and helpful. Please feel free to contact me with any questions. I answer all of my emails; please allow 24-72 hours as we get many questions. You can also find many other interesting studies and articles by clicking on Educational Resources (A task bar on the left) at Body Language Vitamin Company

Michael D. Seidman, MD., FACS

B.S. Human Nutrition

CEO-Body Language Vitamin Co

Director of Otologic/Neurotologic Surgery/Henry Ford Health System

Director of Complementary/Integrative Medicine Henry Ford Health System

Office: 248-661-7211 (Henry Ford Health System)

Body Language Office (voice mail) 877-LIVE-FIT

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